Testosterone is the primary male sex hormone and low levels of this is medically known as hypogonadism. This is when the body fails to produce adequate levels of testosterone. The risk of suffering from hypogonadism increases with a man’s age although it can occur at any stage of life.
There are many and varied causes of low testosterone. Primary hypogonadism is due to issues originating from the testicles themselves whilst secondary hypogonadism can result from pituitary disorders, inflammatory diseases, obesity, certain medications, stress, and aging. By age 70, many men experience a 30-50% decline in testosterone levels compared to their younger years.
Hypogonadism causes both physical and psychological symptoms. Physical symptoms include a reduction in muscle mass and strength, increased body fat (especially around the abdomen), decreased bone density, unexplained fatigue, reduced body hair, and sexual dysfunction including lower sex drive and erectile difficulties (see Erectile Dysfunction).
Psychological effects of low testosterone include depression, irritability, difficulty concentrating, reduced motivation, and low self-esteem.
The impact of low testosterone on a sufferers quality of life can be significant. Beyond the symptoms mentioned above, the condition can lead to strained relationships due to sexual difficulties and mood changes. Diagnosis of low testosterone can be delayed to symptoms overlapping with other conditions. Many men report feeling “less masculine” or experiencing a loss of identity as their bodies and minds change.
The main treatment for Hypogonadism is testosterone replacement therapy (TRT), given as injections, patches, gels, or pellets. Proper treatment can lead to improved energy levels, sexual function, mood, cognitive function, body composition, and overall quality of life.
Alternative approaches include lifestyle modifications – weight management, regular exercise, adequate sleep, stress reduction – and addressing underlying conditions when possible. Some men benefit from clomiphene citrate to stimulate natural testosterone production rather than providing exogenous hormones.
Tostran gel (testosterone) – ADVANZ Pharma
Tostran is a testosterone replacement therapy for men with low testosterone levels. It’s applied as a gel to clean, dry skin once daily, usually on the shoulders, upper arms, or abdomen. The hormone is absorbed through the skin into the bloodstream. Hands should be washed after application, and contact with others should be avoided until the gel has dried.
Common side effects of Tostran gel include skin reactions at the application site such as redness, dryness, acne, and irritation. Acne on other areas of the body and an increase in red blood cell count (which can thicken the blood) have also been reported. Mood changes, headache, and alterations in libido may occur. A key risk with topical testosterone is inadvertent transfer to partners or children through skin contact, which can cause virilisation in women and children. Users should ensure the application site is covered or washed before close physical contact.
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